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KMID : 0380020200350030244
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Korean Journal of Biotechnology and Bioengineering
2020 Volume.35 No. 3 p.244 ~ p.250
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Evaluation of Water Solubilization Technology of Musk through Anti-inflammatory Effect Research
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Lee Hyo-Seong
Kim Yong-Soo
Lee Kyeong-Seob
Han Ji-Hyun
Lee Chan-Yong
Kim Kee-K.
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Abstract
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Musk is a traditional high-grade medical product that has a great anti-inflammatory activity. However, musk is a poorly soluble substance, which is difficult to use in the food and drug field. Therefore, in order to increase the efficacy of musk, research on the water-solubilization of musk is necessary. In this study, we have applied the water-solublization technology to musk and the solubility of musk with water-solubilization technology was compared with the solubility of musk without water-solubilization technology to confirm the water-solubility. Next, we investigated antioxidant efficacy of musk with water-solublization technology and effect of musk with water-solublization technology on anti-inflammatory activity using mouse macrophage RAW 264.7 cells. As a result, musk with water-solublization technology showed excellent radical scavenging ability. the mRNA expressions of IL-1β, IL-6, which cytokines released during inflammatory reactions, were repressed and the activity of mouse macrophages increased by treatment of musk with water-solublization technology. In conclusion, these results suggest that water-solublization technology improved the absorption of musk and musk with water-solublization technology can increase musk's antioxidant activity and anti-inflammatory activity, which can be used in various fields including the food and drug fields.
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KEYWORD
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musk, water-solubilization technology, anti-inflammatory activity
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